Efficacy and adverse effects of rectal thiamylal with oral triclofos for children undergoing magnetic resonance imaging

• Published in: Brain & development (Tokyo. 1979) 2006-04, Vol.28 (3), p.175-177
• Main Authors: Iwata, Seiko, Okumura, Akihisa, Kato, Toru, Itomi, Kazuya, Kuno, Kuniyoshi
• Format: Article
• Language: English
• Subjects: Administration, Oral; Administration, Rectal; Adolescent; Adult; Adverse effect; Anesthetics, Intravenous - administration & dosage; Anesthetics, Intravenous - adverse effects; Anesthetics, Intravenous - therapeutic use; Child; Child, Preschool; Efficacy; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - adverse effects; Hypnotics and Sedatives - therapeutic use; Infant; Infant, Newborn; Magnetic Resonance Imaging - methods; MRI; Organophosphates - administration & dosage; Organophosphates - adverse effects; Organophosphates - therapeutic use; Rectal thiamylal; Retrospective Studies; Sedation; Thiamylal - administration & dosage; Thiamylal - adverse effects
• ISSN: 0387-7604; 1872-7131
• DOI: 10.1016/j.braindev.2005.06.009

We studied the efficacy and adverse effects of rectal thiamylal in combination with oral triclofos in sedation for pediatric magnetic resonance imaging. Five hundred forty-six children underwent MRI examination from January of 1997 to December of 2001. Among them, 10 mg/kg of rectal thiamylal was administrated after oral triclofos in 378 children. Successful sedation was obtained in 321 of 378 patients (85%) after a single rectal administration of thiamylal. Totally, 369 children (98%) could undergo MRI examination completely under successful sedation. Adverse effect was observed only in one patient showing respiratory depression. Rectal thiamylal is effective for sedation for MRI in children. Adverse effect was rare in our patients. Although the risk of side effect was considered to be rare, we should follow principles for the sedation of children.