Clinical efficacy of zonisamide in Lennox–Gastaut syndrome: Korean multicentric experience

Abstract Purpose: To evaluate the efficacy and safety of zonisamide (ZNS) as long-term adjunctive therapy in children with Lennox–Gastaut syndrome (LGS). Method: We evaluated the seizure frequency, cognitive outcomes, and side effects of 62 LGS patients maintained on ZNS for at least 12 months in th...

Full description

Saved in:
Bibliographic Details
Published in:Brain & development (Tokyo. 1979) 2008-04, Vol.30 (4), p.287-290
Main Authors: You, Su Jeong, Kang, Hoon-Chul, Kim, Heung Dong, Lee, Hyun Sug, Ko, Tae-Sung
Format: Article
Language:English
Subjects:
Anticonvulsants - administration & dosage
Anticonvulsants - adverse effects
Child
Child, Preschool
Epilepsy - drug therapy
Female
Follow-Up Studies
Humans
Infant
Isoxazoles - administration & dosage
Isoxazoles - adverse effects
Korea
Lennox–Gastaut syndrome (LGS)
Male
Neurology
Retrospective Studies
Treatment Outcome
Zonisamide (ZNS)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Purpose: To evaluate the efficacy and safety of zonisamide (ZNS) as long-term adjunctive therapy in children with Lennox–Gastaut syndrome (LGS). Method: We evaluated the seizure frequency, cognitive outcomes, and side effects of 62 LGS patients maintained on ZNS for at least 12 months in three tertiary centers. Results: Of the 62 LGS patients maintained on ZNS, 3 (4.8%) had 100% seizure control; 14 (22.6%) had >75% to 50% to 0% to
ISSN:0387-7604
1872-7131
DOI:10.1016/j.braindev.2007.09.004