A trial of lacosamide for benign convulsions with gastroenteritis

Benign convulsions with gastroenteritis are characterized by a cluster of seizures. Sodium channel blockers are efficacious. We prescribed lacosamide, a new channel blocker, for five patients. Patient age ranged from 17 to 33 months; all five experienced 1–4 generalized convulsions persisting for 30...

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Bibliographic Details
Published in:Brain & development (Tokyo. 1979) 2020-08, Vol.42 (7), p.551-554
Main Authors: Numoto, Shingo, Kurahashi, Hirokazu, Iwayama, Hideyuki, Okumura, Akihisa
Format: Article
Language:English
Subjects:
Benign convulsions with gastroenteritis
Child, Preschool
Efficacy
Female
Gastroenteritis - complications
Humans
Infant
Lacosamide
Lacosamide - administration & dosage
Male
Seizures - drug therapy
Seizures - etiology
Tolerability
Voltage-Gated Sodium Channel Blockers - administration & dosage
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Summary:Benign convulsions with gastroenteritis are characterized by a cluster of seizures. Sodium channel blockers are efficacious. We prescribed lacosamide, a new channel blocker, for five patients. Patient age ranged from 17 to 33 months; all five experienced 1–4 generalized convulsions persisting for 30–120 s. One patient exhibited a transient splenial lesion on head magnetic resonance imaging. All received one dose (2 mg/kg) of lacosamide. The convulsions ceased, and no adverse drug effect was noted. A single dose of lacosamide was effective and well-tolerated in five patients with benign convulsions with gastroenteritis.
ISSN:0387-7604
1872-7131
DOI:10.1016/j.braindev.2020.03.006