Interferon modulates central nervous system function

The interferons (IFNs) are an endogenous pleiotropic family of cytokines that perform fundamental physiological functions as well as protecting host organisms from disease and in maintaining homeostasis. This review covers the effects of endogenous IFN on the nervous system. It starts with the descr...

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Bibliographic Details
Published in:Brain research 2012-03, Vol.1442, p.76-89
Main Authors: Reyes-Vázquez, Cruz, Prieto-Gómez, Bertha, Dafny, Nachum
Format: Article
Language:English
Subjects:
Animals
Appetite Regulation
Body Temperature Regulation
brain
Brain - metabolism
Brain - physiology
carcinoma
chronic diseases
chronic hepatitis C
Cytokine
cytokines
death
Depression
Depression - chemically induced
Depression - physiopathology
emotions
Endocrine
endocrine system
Endocrine System - physiology
food consumption
Food ingestion
homeostasis
Humans
Immune system
Immune System - physiology
Interferon receptor
interferons
Interferons - adverse effects
Interferons - physiology
Interferons - therapeutic use
melanoma
Neurology
Neuronal activity
Neurons - physiology
Opioid
Opioid-Related Disorders - metabolism
receptors
Receptors, Interferon - metabolism
sclerosis
Sleep
Temperature
toxicity
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Description
Summary:The interferons (IFNs) are an endogenous pleiotropic family of cytokines that perform fundamental physiological functions as well as protecting host organisms from disease and in maintaining homeostasis. This review covers the effects of endogenous IFN on the nervous system. It starts with the description of its receptors, followed how it modulate neuronal activity, mood, sleep, temperature, the endocrine system, the opioid system and how it regulate food consumption and the immune system. Similar to other multifunctional cytokines, an excessive or inappropriate activity of IFNs can cause toxicity and even death. Furthermore, IFNs are currently the major treatment modality for several malignant and non-malignant diseases such as chronic hepatitis C and B, multiple sclerosis, hematological malignancies, malignant melanoma, renal cell carcinoma, etc.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2011.09.061