Effect of MPTP on mRNA expression of PGC-1α in mouse brain

Highlights • Expression of PGC-1α transcripts was assessed following different MPTP treatments. • PGC-1α expression was significantly elevated ninety minutes after acute MPTP treatment. • This elevation did not persist 7 days following the last MPTP injection. • Chronic low-dose of MPTP as precondit...

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Bibliographic Details
Published in:Brain research 2017-04, Vol.1660, p.20-26
Main Authors: Torok, Rita, Salamon, Andras, Sumegi, Evelin, Zadori, Denes, Veres, Gabor, Molnar, Mate Fort, Vecsei, Laszlo, Klivenyi, Peter
Format: Article
Language:English
Subjects:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage
3,4-Dihydroxyphenylacetic Acid - metabolism
Animals
Brain - drug effects
Brain - metabolism
CNS-PGC-1α
Dopamine
Dopamine - metabolism
Dopamine Agents - administration & dosage
FL-PGC-1α
Gene Expression - drug effects
Homovanillic Acid - metabolism
Male
Mice, Inbred C57BL
MPTP
MPTP Poisoning - metabolism
Neurology
NT-PGC-1α
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism
Preconditioning
Protein Isoforms - metabolism
Random Allocation
RNA, Messenger - metabolism
Time Factors
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Summary:Highlights • Expression of PGC-1α transcripts was assessed following different MPTP treatments. • PGC-1α expression was significantly elevated ninety minutes after acute MPTP treatment. • This elevation did not persist 7 days following the last MPTP injection. • Chronic low-dose of MPTP as preconditioning induced no changes in PGC-1α levels. • MPTP may induce a short-term compensatory mechanism via the PGC-1α system.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2017.01.032