1-Phenil-6,7-dihydroxy-isochroman inhibits inflammatory activation of microglia

Highlights • L137 prevents pro-inflammatory mediator production by activated primary rat microglia cells. • L137 reduces LPS-induced inflammatory response in microglial cells. • Effects of 1-phenyl-6,7-dihydroxy-isochroman on microglial cell activation. • Anti-inflammatory effects of 1-phenyl-6,7-di...

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Bibliographic Details
Published in:Brain research bulletin 2013-06, Vol.95, p.33-39
Main Authors: Togna, Anna Rita, Latina, Valentina, Trefiletti, Giuliana, Guiso, Marcella, Moschini, Sabina, Togna, Giuseppina I
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory activity
Anti-Inflammatory Agents - pharmacology
Chromans - pharmacology
Cyclooxygenase
Dinoprostone - metabolism
Inflammation - metabolism
Inflammation Mediators - metabolism
Interleukin-6 - metabolism
Isochromans
Lipopolysaccharides - pharmacology
Macrophage Activation - drug effects
Microglia - drug effects
Microglia - metabolism
Microglia activation
Neurology
NF-kappa B - metabolism
Nitric Oxide - biosynthesis
Nitric Oxide Synthase Type II - metabolism
Pro-inflammatory mediators
Prostaglandin-Endoperoxide Synthases - metabolism
Rats
Signal Transduction - drug effects
Tumor Necrosis Factor-alpha - metabolism
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Summary:Highlights • L137 prevents pro-inflammatory mediator production by activated primary rat microglia cells. • L137 reduces LPS-induced inflammatory response in microglial cells. • Effects of 1-phenyl-6,7-dihydroxy-isochroman on microglial cell activation. • Anti-inflammatory effects of 1-phenyl-6,7-dihydroxy-isochroman on microglial cells. • L137 as potential lead compound for the development of anti-inflammatory and potentially neuroprotective agents.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2013.03.001