The effects of baseline length in Computed Tomography perfusion of liver

Computed Tomography perfusion (CTp) of liver is very attractive for predictive and prognostic purposes, but motion artefacts and radiation dose connected to duration of examinations jeopardize the reproducibility of perfusion values, thwarting CTp daily application in clinics. The goal is showing to...

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Bibliographic Details
Published in:Biomedical signal processing and control 2020-09, Vol.62, p.102135, Article 102135
Main Authors: Malavasi, Silvia, Bevilacqua, Alessandro, Gavelli, Giampaolo, Barone, Domenico
Format: Article
Language:English
Subjects:
Baseline
Blood flow
Measurement errors
Reproducibility
Time concentration curves
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Summary:Computed Tomography perfusion (CTp) of liver is very attractive for predictive and prognostic purposes, but motion artefacts and radiation dose connected to duration of examinations jeopardize the reproducibility of perfusion values, thwarting CTp daily application in clinics. The goal is showing to what extent these issues can be faced by shortening the CTp unenhanced stage (i.e., the baseline). 59 patients with colorectal cancer underwent undelayed hepatic CTp examinations. For each patient, fifteen virtual examinations Eτsimulating different scan delays τ∈[1..15] s were achieved from the undelayed original sequence E0. Absolute (AD), percentage (PD) and compound differences (CDτ) were computed between E0 and each Eτfor baseline and perfusion values and measured in HU and arbitrary units (a.u.), respectively. Patients were grouped and counted based on the differences achieved. Maximum perfusion CDτ
ISSN:1746-8094
1746-8108
DOI:10.1016/j.bspc.2020.102135