Docetaxel-induced growth inhibition and apoptosis in androgen independent prostate cancer cells are enhanced by 1α,25-dihydroxyvitamin D3

Abstract Pre-treatment with high-dose 1α,25-dihydroxyvitamin D3 (1,25-VD) enhanced the antitumor activity of docetaxel in the androgen-independent prostate cancer cell line, PC-3. The effect manifested as an increasing population of apoptotic cells and amount of pro-apoptotic protein, Bax, under com...

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Bibliographic Details
Published in:Cancer letters 2007-03, Vol.247 (1), p.122-129
Main Authors: Ting, Huei-Ju, Hsu, Jeffery, Bao, Bo-Yin, Lee, Yi-Fen
Format: Article
Language:English
Subjects:
Hematology, Oncology and Palliative Medicine
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Summary:Abstract Pre-treatment with high-dose 1α,25-dihydroxyvitamin D3 (1,25-VD) enhanced the antitumor activity of docetaxel in the androgen-independent prostate cancer cell line, PC-3. The effect manifested as an increasing population of apoptotic cells and amount of pro-apoptotic protein, Bax, under combined treatment compared with single treatment of either 1,25-VD or docetaxel alone. We further demonstrated that pre-treatment with 1,25-VD reduced the expression of multidrug resistance-associated protein-1 at both the mRNA and protein levels. This suggests pre-treatment with 1,25-VD can potentiate cytotoxicity of docetaxel in PC-3 due to 1,25-VD reducing multidrug resistance-associated protein-1 expression.
ISSN:0304-3835
DOI:10.1016/j.canlet.2006.03.025