Thymosinα1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells

Abstract In this study, we investigated the expression and function of thymosinα1 (Thyα1) in human pancreatic cancer. We found that human pancreatic cancer cell lines Panc-1, Panc03.27, ASPC-1, and PL45 cells significantly over-expressed the mRNA of Thyα1 as compared to the normal human pancreatic d...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2007-04, Vol.248 (1), p.58-67
Main Authors: Li, Min, Feurino, Louis W, Li, Fei, Wang, Hao, Zhai, Qihui, Fisher, William E, Chen, Changyi, Yao, Qizhi
Format: Article
Language:English
Subjects:
Cell proliferation
Cytokine
Hematology, Oncology and Palliative Medicine
Pancreatic cancer
Phosphorylation
Thymosinα1
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract In this study, we investigated the expression and function of thymosinα1 (Thyα1) in human pancreatic cancer. We found that human pancreatic cancer cell lines Panc-1, Panc03.27, ASPC-1, and PL45 cells significantly over-expressed the mRNA of Thyα1 as compared to the normal human pancreatic ductal epithelium (HPDE) cells.. Thyα1 mRNA and protein levels were also over-expressed in clinical pancreatic adenocarcinoma specimens. In addition, synthetic Thyα1 significantly promoted Panc-1 cell proliferation and increased phosphorylation of ERK1/2 and JNK. Furthermore, Thyα1 increased the secretion of multiple cytokines including IL-10, IL-13, and IL-17 in Panc-1 cells. Thus, Thyα1 may have a new role in pancreatic cancer pathogenesis.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2006.05.019