Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice

Highlights • Rottlerin inhibits pancreatic cancer tumor growth in nude mice. • Rottlerin inhibits pancreatic cancer cell growth isolated from KrasG12D mice. • Rottlerin exerts its effects by inhibiting Akt, Notch and Shh pathways. • Rottlerin can be used for the treatment of pancreatic cancer....

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2014-10, Vol.353 (1), p.32-40
Main Authors: Huang, Minzhao, Tang, Su-Ni, Upadhyay, Ghanshyam, Marsh, Justin L, Jackman, Christopher P, Srivastava, Rakesh K, Shankar, Sharmila
Format: Article
Language:English
Subjects:
Akt
Cancer prevention
Hematology, Oncology and Palliative Medicine
Notch
Pancreatic cancer
Rottlerin
Sonic Hedgehog
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Rottlerin inhibits pancreatic cancer tumor growth in nude mice. • Rottlerin inhibits pancreatic cancer cell growth isolated from KrasG12D mice. • Rottlerin exerts its effects by inhibiting Akt, Notch and Shh pathways. • Rottlerin can be used for the treatment of pancreatic cancer.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.06.021