An EGF receptor targeting Ranpirnase-diabody fusion protein mediates potent antitumour activity in vitro and in vivo

Highlights • A novel immunoRNase mediates potent killing of EGFR targeted cancer cells. • Antibody targeted delivery completely abolishes non-specific cytotoxicity of RNase. • Dimeric ImmunoRNase is far more cytotoxic than a monomeric counterpart. • ImmunoRNase significantly prolongs survival of tum...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2015-02, Vol.357 (1), p.364-373
Main Authors: Kiesgen, Stefan, Arndt, Michaela A.E, Körber, Christoph, Arnold, Ulrich, Weber, Tobias, Halama, Niels, Keller, Armin, Bötticher, Benedikt, Schlegelmilch, Anne, Liebers, Nora, Cremer, Martin, Herold-Mende, Christel, Dyckhoff, Gerhard, Federspil, Philippe A, Jensen, Alexandra D, Jäger, Dirk, Kontermann, Roland E, Mier, Walter, Krauss, Jürgen
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - enzymology
Cell Line, Tumor
Diabody
Disease-Free Survival
EGFR
ErbB Receptors - metabolism
Female
Head and Neck Neoplasms - drug therapy
Head and Neck Neoplasms - enzymology
Hematology, Oncology and Palliative Medicine
Humans
immunoRNase
Mice
Mice, Inbred BALB C
Mice, Nude
Onconase
Ranpirnase
Recombinant Fusion Proteins - pharmacology
Ribonucleases - genetics
Ribonucleases - pharmacology
Squamous Cell Carcinoma of Head and Neck
Xenograft Model Antitumor Assays
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • A novel immunoRNase mediates potent killing of EGFR targeted cancer cells. • Antibody targeted delivery completely abolishes non-specific cytotoxicity of RNase. • Dimeric ImmunoRNase is far more cytotoxic than a monomeric counterpart. • ImmunoRNase significantly prolongs survival of tumour xenografted mice.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.11.054