Myeloma appearance after local external beam radiotherapy jet: Is it a new entity?

Multiple myeloma, also known as Kahler's disease, is a cancer of plasma cells that abnormally accumulate in bone marrow. Radiation therapy may be indicated in multiple myeloma to relieve pain, alleviate spinal cord compression or reduce tumor mass. We report the case of a patient presenting a m...

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Bibliographic Details
Published in:Cancer radiothérapie 2013-11, Vol.17 (7), p.668-670
Main Authors: Maalej, M., Belaïd, A., Laabidi, M., Ben Romdhane, N., Kochbati, L.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Champ
Cutaneous
Cutané
Field
Hemopathies
Medical sciences
Multiple myeloma
Myélome multiple
Radiation therapy
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Radiothérapie
Relapse
Récidive
Tumors
Citations: Items that this one cites
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Summary:Multiple myeloma, also known as Kahler's disease, is a cancer of plasma cells that abnormally accumulate in bone marrow. Radiation therapy may be indicated in multiple myeloma to relieve pain, alleviate spinal cord compression or reduce tumor mass. We report the case of a patient presenting a multiple myeloma, treated with radiation therapy for a spinal cord compression, who developed, eleven months later, an in-field subcutaneous relapse. We called this phenomenon myeloma appearance after local external beam radiotherapy jet (MAALEJ). A review of literature was performed trying to explain this uncommon relapse feature. Le myélome multiple ou maladie de Kahler est une hémopathie maligne caractérisée par le développement d’un clone de plasmocytes tumoraux envahissant la moelle hématopoïétique. La radiothérapie est souvent indiquée dans le traitement des lésions plasmocytaires symptomatiques. Elle permet de réduire significativement la masse tumorale irradiée en diminuant ainsi la douleur et les signes de compression. Nous rapportons l’observation originale d’une patiente irradiée pour une localisation vertébrale compressive d’un myélome multiple qui a été atteinte d’une récidive plasmocytaire sous-cutanée en plein champ d’irradiation. Ce phénomène inhabituel a été baptisé myeloma appearance after local external beam radiotherapy jet (MAALEJ). Une revue de la littérature a été réalisée afin de tenter d’expliquer cette récidive inhabituelle de myélome multiple.
ISSN:1278-3218
1769-6658
DOI:10.1016/j.canrad.2013.09.003