DNA and PNA as templates for building nanoassemblies via electrostatic complexation with gold nanoparticles

Organisation of nanoparticles on structurally well-defined templates is a first step towards creating nanomachines. In this respect, nucleic acids are ideal structural templates and a variety of secondary structures realizable from DNA/RNA––e.g., duplexes, hairpins, triplexes, cruciforms, tetraplexe...

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Bibliographic Details
Published in:Current applied physics 2005-02, Vol.5 (2), p.102-107
Main Authors: Gourishankar, A., Shukla, S., Pasricha, R., Sastry, M., Ganesh, K.N.
Format: Article
Language:English
Subjects:
DNA
DNA-gold nanoparticle interactions
Nanoassemblies
PNA
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Summary:Organisation of nanoparticles on structurally well-defined templates is a first step towards creating nanomachines. In this respect, nucleic acids are ideal structural templates and a variety of secondary structures realizable from DNA/RNA––e.g., duplexes, hairpins, triplexes, cruciforms, tetraplexes can be exploited to engineer nanoparticle organization at will. We have used oligonucleotides and their analogues such as phosphorothioates and peptide nucleic acids to electrostatically encapsulate cationic-capped gold nanoparticles. This article describes synthesis and characterization of DNA/PNA-gold nanoparticle composites using TEM and UV-Tm techniques. These types of assemblies may have potential for creating nanowires and lithographic circuits.
ISSN:1567-1739
1878-1675
DOI:10.1016/j.cap.2004.06.020