Structured carbon haemoadsorbents for the removal of middle molecular weight toxins

There is continued interest in the development of novel haemoadsorbents for the removal of middle molecular weight molecules from blood in patients suffering with chronic renal failure. Conventional activated carbons have shown poor biocompatibility whereas polymer coated carbons have been applied w...

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Bibliographic Details
Published in:Carbon (New York) 2005-09, Vol.43 (11), p.2317-2329
Main Authors: Malik, D.J., Warwick, G.L., Mathieson, I., Hoenich, N.A., Streat, M.
Format: Article
Language:English
Subjects:
Activated carbon
Activation
Adsorption
Biocompatibility
Cross-disciplinary physics: materials science
rheology
Exact sciences and technology
Fullerenes and related materials
diamonds, graphite
Materials science
Physics
Specific materials
X-ray photoelectron spectroscopy
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Summary:There is continued interest in the development of novel haemoadsorbents for the removal of middle molecular weight molecules from blood in patients suffering with chronic renal failure. Conventional activated carbons have shown poor biocompatibility whereas polymer coated carbons have been applied with limited success. The external biocompatible coating significantly reduces the adsorption capacity for middle molecules due to size exclusion and slows down the adsorption kinetics due to mass transport limitations. In this work, we show that polymer derived mesoporous activated carbons (pore size in the range 2–50 nm) and surface area of between 400 and 800 m 2/g are efficient adsorbents for middle molecular weight species such as interleukin IL-1beta.
ISSN:0008-6223
1873-3891
DOI:10.1016/j.carbon.2005.04.038