MXene/CNTs/Cu-MOF electrochemical probe for detecting tyrosine

Tyrosine is the precursor of some neurotransmitters such as thyroxine and dopamine. It has the effect of regulating emotions and stimulating the nervous system. Changes in tyrosine levels in the human body are associated with certain diseases. Therefore, it is very necessary to prepare a new type of...

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Bibliographic Details
Published in:Carbon (New York) 2022-10, Vol.199, p.110-118
Main Authors: Chen, Jing, Chen, Ying, Li, Shuying, Yang, Jiao, Dong, Jianbin, Lu, Xiaoquan
Format: Article
Language:English
Subjects:
Carbon nanotubes
CuMOF
Electrochemical sensor
Enzyme-free
Human serum
MXene
Tyrosine
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Summary:Tyrosine is the precursor of some neurotransmitters such as thyroxine and dopamine. It has the effect of regulating emotions and stimulating the nervous system. Changes in tyrosine levels in the human body are associated with certain diseases. Therefore, it is very necessary to prepare a new type of tyrosine sensor. In this work, an enzyme-free electrochemical sensor based on MXene/CNTs/CuMOF composite was developed for the detection of tyrosine. Embedding carbon nanotubes (CNTs) into MXene effectively prevented the aggregation of MXene sheets. Further modification of MXene/CNTs materials with CuMOF octahedral particles with porous structure can improve the porosity and catalytic capability of the composites. Under the optimal detection conditions, the prepared sensor has good linearity in the detection of tyrosine within range 0.53 μM–232.46 μM with a limit of detection (LOD) of 0.19 μM. The stability and selectivity of the sensor is high, and can be used to detect tyrosine in human serum. [Display omitted]
ISSN:0008-6223
1873-3891
DOI:10.1016/j.carbon.2022.07.021