New types of α-amylase enzyme-inhibitory polysaccharides from d-glucal

We describe the synthesis of new types of α-amylase enzyme-inhibitory polysaccharides obtained by polycondensation of 3,6-Di-O-acetyl- d-glucal followed by deacetylation. The structure of the resulting new polysaccharides containing unique 2,3-unsaturated hexopyranose repeating units were unambiguou...

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Bibliographic Details
Published in:Carbohydrate polymers 2006, Vol.63 (1), p.136-140
Main Authors: Kéki, Sándor, Batta, Gyula, Bereczki, Ilona, Fejes, Zsolt, Nagy, Lajos, Zajácz, Ágnes, Kandra, Lili, Kiricsi, Imre, Deák, György, Zsuga, Miklós, Herczegh, Pál
Format: Article
Language:English
Subjects:
alpha-amylase
Applied sciences
chemical reactions
enzyme inhibitors
Exact sciences and technology
Ferrier rearrangement
MALDI-TOF MS
NMR
Physicochemistry of polymers
Polycondensation
Polysaccharides
synthesis
Synthetic biopolymers
Unsaturated glycals
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Summary:We describe the synthesis of new types of α-amylase enzyme-inhibitory polysaccharides obtained by polycondensation of 3,6-Di-O-acetyl- d-glucal followed by deacetylation. The structure of the resulting new polysaccharides containing unique 2,3-unsaturated hexopyranose repeating units were unambiguously determined by NMR and MALDI-TOF MS methods. The deacetylated polysaccharides proved to be a semicompetitive inhibitor of the human salivary amylase enzyme.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2005.07.036