Modified gums: Approaches and applications in drug delivery

Gums are naturally occurring components in plants, which are essentially cheap and plentiful. They have diverse applications as thickeners, emulsifiers, viscosifiers, sweeteners etc. in confectionary, and as binders and drug release modifiers in pharmaceutical dosage forms. However, most of the gums...

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Bibliographic Details
Published in:Carbohydrate polymers 2011-01, Vol.83 (3), p.1031-1047
Main Authors: Rana, Vikas, Rai, Parshuram, Tiwary, Ashok K., Singh, Ram S., Kennedy, John F., Knill, Charles J.
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
crosslinking
derivatization
Drug delivery
drug delivery systems
drug formulations
drugs
emulsifiers
Exact sciences and technology
General pharmacology
Gum derivatives
ions
Mechanisms of cross linking of gums
Medical sciences
Modified gums
Natural gums
Natural polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
polymers
solubility
Starch and polysaccharides
sweeteners
sweets
thickeners
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Summary:Gums are naturally occurring components in plants, which are essentially cheap and plentiful. They have diverse applications as thickeners, emulsifiers, viscosifiers, sweeteners etc. in confectionary, and as binders and drug release modifiers in pharmaceutical dosage forms. However, most of the gums in their putative form are required in very high concentrations to successfully function as drug release modifiers in dosage forms due to their high swellability/solubility at acidic pH. Hence, gums need to be modified to alter their physicochemical properties. This article is aimed at discussing the modification of gums through derivatisation of functional groups, grafting with polymers, cross-linking with ions etc. The factors influencing these processes in the pursuit of making them suitable for modifying the drug release properties of pharmaceutical dosage forms and for other purposes is discussed with respect to optimization of their performance.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2010.09.010