Structural features and antitussive activity of water extracted polysaccharide from Adhatoda vasica

Antitussive drugs are amongst the most widely used medications worldwide; however no new class of drugs has been introduced into the market for many years. Natural compounds offer interesting pharmacological perspectives for antitussive drug development. In this study, we have analyzed a pectic arab...

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Bibliographic Details
Published in:Carbohydrate polymers 2011-02, Vol.83 (4), p.1970-1974
Main Authors: Chattopadhyay, Nabanita, Nosál’ová, Gabriella, Saha, Sudipta, Bandyopadhyay, Shruti S., Flešková, Dana, Ray, Bimalendu
Format: Article
Language:English
Subjects:
Adhatoda vasica
Antitussive activity
antitussive agents
Applied sciences
arabinogalactans
Biological and medical sciences
body weight
citric acid
ethanol
Exact sciences and technology
guinea pigs
Justicia adhatoda
markets
Medical sciences
Natural polymers
Pectic arabinogalactan
Pharmacology. Drug treatments
Physicochemistry of polymers
Respiratory system
Starch and polysaccharides
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Summary:Antitussive drugs are amongst the most widely used medications worldwide; however no new class of drugs has been introduced into the market for many years. Natural compounds offer interesting pharmacological perspectives for antitussive drug development. In this study, we have analyzed a pectic arabinogalactan isolated from Adhatoda vasica by aqueous extraction and precipitation with ethanol. This polysaccharide is branched and consisted mainly of 1,3-/1,3,6-linked galactopyranosyl and 1,5-/1,3,5-linked arabinofuranosyl residues. Peroral administration of this arabinogalactan (50 mg kg −1 body weight) inhibited the number of coughs induced by citric acid in guinea pigs and slightly decreased the values of specific airway resistance.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2010.11.002