In vitro characterization, and in vivo studies of crosslinked lactosaminated carboxymethyl chitosan nanoparticles

The liver targeting and controlled release nanoparticles based on carboxymethyl chitosan derivatives were prepared: firstly, novel thiolated lactosaminated carboxymethyl chitosan (LAC-CMC) was synthesized, its chemical structure was characterized by 1H NMR spectroscopy. Then, glycyrrhizic acid was c...

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Bibliographic Details
Published in:Carbohydrate polymers 2011-03, Vol.84 (3), p.1048-1053
Main Authors: Zheng, Hua, Zhang, Xueqiong, Yin, Yihua, Xiong, Fuliang, Gong, Xiaoyu, Zhu, Zhongjia, Lu, Bo, Xu, Peihu
Format: Article
Language:English
Subjects:
Applied sciences
Biodistribution
Biological and medical sciences
Carboxymethyl chitosan
chitosan
crosslinking
drug delivery systems
Exact sciences and technology
excretion
Galactose group
General pharmacology
glutathione
glycyrrhizin
in vivo studies
kidneys
liver
Medical sciences
nanoparticles
Natural polymers
nuclear magnetic resonance spectroscopy
Pharmaceutical technology. Pharmaceutical industry
Pharmacokinetic
Pharmacology. Drug treatments
Physicochemistry of polymers
Starch and polysaccharides
Thiol
tissue distribution
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Summary:The liver targeting and controlled release nanoparticles based on carboxymethyl chitosan derivatives were prepared: firstly, novel thiolated lactosaminated carboxymethyl chitosan (LAC-CMC) was synthesized, its chemical structure was characterized by 1H NMR spectroscopy. Then, glycyrrhizic acid was chosen as model drug and encapsulated within thiolated LAC-CMC nanoparticles through ionic gelification. The crosslinked glycyrrhizic acid-loaded nanoparticles dissociated to release drug in the presence of glutathione (GSH) at a concentration comparable to the intracellular environment, featuring the potential ability of this system for intracellular delivery. Crosslinked nanoparticles modify the tissue distribution profile of the glycyrrhizic acid solution, the kidney excretion rate is reduced and the drug accumulation in the liver is increased. According to these results, the nanoparticles have the potential to be used as drug delivery system with hepatic targeting and controlled release properties.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2010.12.067