Al +3 ion cross-linked and acetalated gellan hydrogel network beads for prolonged release of glipizide

Considering relatively fast drug release rate of Ca +2/gellan beads in phosphate buffer solution, a novel glipizide-loaded bead system was developed through ionotropic gelation of gellan with trivalent Al +3 ions and covalent cross-linking with glutaraldehyde (GA). Following GA-treatment, spherical...

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Bibliographic Details
Published in:Carbohydrate polymers 2011, Vol.85 (1), p.164-172
Main Authors: Maiti, Sabyasachi, Ranjit, Somdipta, Mondol, Ranjit, Ray, Somasree, Sa, Biswanath
Format: Article
Language:English
Subjects:
aluminum
Applied sciences
Biological and medical sciences
crosslinking
Drug release
drugs
Entrapment efficiency
Exact sciences and technology
gelation
Gellan gum
General pharmacology
glipizide
glutaraldehyde
hydrocolloids
Hydrogel bead
Ionotropic gelation
ions
Medical sciences
Natural polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
phosphates
Physicochemistry of polymers
polymers
Starch and polysaccharides
Swelling
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Summary:Considering relatively fast drug release rate of Ca +2/gellan beads in phosphate buffer solution, a novel glipizide-loaded bead system was developed through ionotropic gelation of gellan with trivalent Al +3 ions and covalent cross-linking with glutaraldehyde (GA). Following GA-treatment, spherical Al +3/gellan beads contracted leaving wrinkles on bead surface. A maximum of 97.67% drug entrapment efficiency was achieved; however GA-treatment reduced the same by 11.89%. All the beads released only 10% drug in acidic medium in 2 h; however it was found 38–47% for Al +3/gellan beads and only 15% for GA-treated beads in weakly alkaline medium. The drug release did correlate well with their swelling behaviors. The anomalous drug transport mechanism shifted to super case II transport for GA-treated beads, where the polymer relaxation phenomenon was dominant. The drug was relatively stable, amorphous in the beads. Thus both GA-treated and -untreated Al +3/gellan beads could be useful carriers for the controlled oral delivery of glipizide.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2011.02.010