A review of polysaccharide cytotoxic drug conjugates for cancer therapy

► Biocompatibility, molecular weight and type of linkers are the core factors in rational drug-conjugate design. ► Conjugates generally show lower in vitro cytotoxicity in comparison with free drug. ► Superiority of the conjugates is the performance in vivo where distribution determines efficacy and...

Full description

Saved in:
Bibliographic Details
Published in:Carbohydrate polymers 2013-02, Vol.92 (2), p.1280-1293
Main Authors: Goodarzi, N., Varshochian, R., Kamalinia, G., Atyabi, F., Dinarvand, R.
Format: Article
Language:English
Subjects:
Animals
Anti-cancer drugs
Antineoplastic agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Application fields
Applied sciences
Biological and medical sciences
Chemotherapy
Chitosan
Conjugation
Dextran
Exact sciences and technology
Humans
Hyaluronic acid
Medical sciences
Neoplasms - drug therapy
Pharmacology. Drug treatments
Polymer industry, paints, wood
Polysaccharide
Polysaccharides - chemistry
Polysaccharides - metabolism
Technology of polymers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:► Biocompatibility, molecular weight and type of linkers are the core factors in rational drug-conjugate design. ► Conjugates generally show lower in vitro cytotoxicity in comparison with free drug. ► Superiority of the conjugates is the performance in vivo where distribution determines efficacy and safety. ► Better simulation and using more reliable in vitro cell culture models accelerate finding the best in vivo candidates. The most considerable challenges facing effective cancer therapy are systemic toxicity of cytotoxic drugs, their lack of tumor localizing and an even distribution throughout the whole body. Besides, short half-lives and undesirable pharmacokinetics are among the other drawbacks that inhibit effective cancer chemotherapy. Conjugation of low molecular weight drugs to polysaccharides has been used as a way to address these problems. This review will focus on polysaccharide drug conjugates and will provide an overview on various conjugation studies which have been accomplished for these carriers with cytotoxic drugs. Although a wide variety of anticancer agents including some toxins have been the subject of conjugation techniques, in this review, low molecular weight cytotoxic drugs conjugated covalently to the carriers are considered.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2012.10.036