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Oil-in-water emulsions stabilized by sodium phosphorylated chitosan
•A new bio-based emulsifier for oil-in-water emulsion was proposed.•Sodium phosphorylated chitosan emulsion can be used to encapsulated lipophilic drug.•Encapsulation efficiency for naproxen was as high as 91%.•The emulsifier exhibited good protective substance and sustained release. Oil-in-water (O...
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Published in: | Carbohydrate polymers 2013-07, Vol.96 (1), p.82-90 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •A new bio-based emulsifier for oil-in-water emulsion was proposed.•Sodium phosphorylated chitosan emulsion can be used to encapsulated lipophilic drug.•Encapsulation efficiency for naproxen was as high as 91%.•The emulsifier exhibited good protective substance and sustained release.
Oil-in-water (O/W) emulsions with sodium phosphorylated chitosan (PCTS) were obtained via simple emulsification. PCTS in aqueous solution was amphiphilic with a hydrophilic–lipophilic balance (HLB) of 19 and a critical aggregation concentration (CAC) of 0.13% w/v. The emulsifying efficiency and emulsion stability of PCTS over oil droplets were evaluated in terms of the droplet size, droplet size distribution and microscopic observation using confocal laser scanning microscopy. PCTS preferred to cover oil droplets to produce an O/W emulsion and formed long term stable particles (90 days storage at room temperature) when using PCTS concentrations from above the CAC to 3% w/v. However, emulsions formed from PCTS concentrations below the CAC or over 3% w/v were unstable with particle agglomeration by flocculation after only 7 days storage, although they reverted to individual droplets that retained their integrity in acidic conditions. Overall, PCTS forms effective stable O/W encapsulated particles with potential applications in lipophilic drug encapsulation via a simple emulsion system. |
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ISSN: | 0144-8617 1879-1344 |
DOI: | 10.1016/j.carbpol.2013.03.065 |