Novel multifunctional colloidal carbohydrate nanofiber electrolytes with excellent conductivity and responses to bone cancer cells

• Published in: Carbohydrate polymers 2015-11, Vol.133, p.624-636
• Main Authors: Gökmen, Fatma Özge, Rzayev, Zakir M.O., Salimi, Kouroush, Bunyatova, Ulviya, Acar, Selim, Salamov, Bahtiyar, Türk, Mustafa
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Bone cancer cells; Bone Neoplasms - pathology; Carbohydrates - chemistry; Carbohydrates - pharmacology; Cell Line, Tumor; Colloids; Conductivity; Electric Conductivity; Electrolytes - chemistry; Electrospinning; Humans; Morphology; Na-CMC; Nanocomposites; Nanocomposites - chemistry; Nanofibers; Nanofibers - chemistry; Organoclay; Polyvinyl Alcohol - chemistry; PVA; Structure–property relationships; Surface Properties
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2015.06.106

[Display omitted] •The multifunctional carbohydrate NFCs were fabricated by green reactive electrospinning.•The incorporation of FA (0.5%) essentialy improved morphology and conductivity of NFCs.•The effects of temperature, pressure and conduct time on electrical properties were evaluated.•The cytotoxic/apoptotic/necrotic analyses were confirmed anticancer activity of FA-NFCs.•Reported conductivity and anticancer activity of novel carbohydrate NFCs for the first time. This work presents a new approach to fabricating novel polymer nanofiber composites (NFCs) from water solution blends of PVA (hydrolyzed 89%)/ODA–MMT and Na–CMC/ODA–MMT nanocomposites as well as their folic acid (FA) incorporated modifications (NC-3-FA and NC-4-FA) through green electrospinning nanotechnology. The chemical and physical structures and surface morphology of the nanofiber composites were confirmed. Significant improvements in nanofiber morphology and size distribution of the NFC-3-FA and NFC-4-FA nanofibers with lower average means 110 and 113nm compared with those of NFC-1/NFC-2 nanofibers (270 and 323nm) were observed. The structural elements of polymer NFCs, particularly loaded partner NC-2, plays an important role in chemical and physical interfacial interactions, phase separation processing and enables the formation of nanofibers with unique morphology and excellent conductivity (NFC-3-FA 3.25×10−9S/cm and NFC-4-FA 8.33×10−4S/cm). This is attributed to the higher surface contact areas and multifunctional self-assembled supramacromolecular nanostructures of amorphous colloidal electrolytes. The anticancer activity of FA-containing nanofibers against osteocarcinoma cells were evaluated by cytotoxicity, apoptotic and necrotic analysis methods.