Development and physicochemical characterization of alginate composite film loaded with simvastatin as a potential wound dressing

• Published in: Carbohydrate polymers 2016-02, Vol.137, p.295-304
• Main Authors: Rezvanian, Masoud, Amin, Mohd Cairul Iqbal Mohd, Ng, Shiow-Fern
• Format: Article
• Language: English
• Subjects: Alginate; Alginates - chemistry; Bandages; Cell Survival - drug effects; Cells, Cultured; Composite film; Film wound dressing; Glucuronic Acid - chemistry; Hexuronic Acids - chemistry; Humans; Pectin; Pectins - chemistry; Simvastatin; Simvastatin - chemistry; Simvastatin - pharmacology; Spectroscopy, Fourier Transform Infrared; Wound Healing - drug effects; X-Ray Diffraction
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2015.10.091

Previously, studies have demonstrated that topical application of simvastatin can promote wound healing in diabetic mice via augmentation of angiogenesis and lymphangiogenesis. This study aimed to formulate and characterize simvastatin in alginate-based composite film wound dressings. Biopolymers used for composite films were sodium alginate blended with pectin or gelatin. The films were prepared and characterized based on their physical properties, surface morphology, mechanical strength and rheology. Then, in vitro drug releases from the films were investigated and, finally, the cell viability assay was performed to assess the cytotoxicity profile. From the pre-formulation studies, alginate/pectin composite film showed to possess desirable wound dressing properties and superior mechanical properties. The in vitro drug release profile revealed that alginate/pectin film produced a controlled release drug profile, and cell viability assay showed that the film was non-toxic. In summary, alginate/pectin composite film is suitable to be formulated with simvastatin as a potential wound dressing.