Identification of a new bis-amino acid glycoside selectively toxic to multiple myeloma cells

•One hit is identified to be selectively toxic to multiple myeloma cells.•The hit is not toxic to a control cell line.•The hit induced apoptosis of multiple myeloma cells. A bis-triazolyl phenylalaninyl galactoside was synthesized by a two-fold click reaction between an azido phenylalanine and a di-...

Full description

Saved in:
Bibliographic Details
Published in:Carbohydrate research 2014-07, Vol.394, p.39-42
Main Authors: Cheng, Chao-Ying, Feng, Yan-Yan, Zang, Yi, Li, Jia, He, Xiao-Peng, Chen, Guo-Rong
Format: Article
Language:English
Subjects:
Amino acid
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis - drug effects
Cell Line, Tumor - drug effects
Click Chemistry
Cytotoxicity
Drug Screening Assays, Antitumor
Glycosides - chemistry
Humans
Multiple myeloma
Multiple Myeloma - drug therapy
Multiple Myeloma - pathology
Poly(ADP-ribose) Polymerases - metabolism
Sugar
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•One hit is identified to be selectively toxic to multiple myeloma cells.•The hit is not toxic to a control cell line.•The hit induced apoptosis of multiple myeloma cells. A bis-triazolyl phenylalaninyl galactoside was synthesized by a two-fold click reaction between an azido phenylalanine and a di-O-propynyl galactoside. By a cytotoxicity assay the compound was determined to be selectively toxic for multiple myeloma (MM) among a series of cancer cell lines with no toxicity to a control cell line. A Western blot analysis suggested that this compound could potentiate the cleavage of poly ADP-ribose polymerase in MM cells, leading to apoptosis.
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2014.05.014