Efficient heterogeneous racemization of secondary alcohols: Convenient synthesis of 17α-estradiol 3-methyl ether

Racemization of optically active secondary alcohols was performed on a heterogeneous Ru/Al 2O 3 catalyst under mild reaction conditions. The supported ruthenium catalyst is readily available, inexpensive, and capable of being recycled. It successfully racemizes secondary alcohols without any additiv...

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Bibliographic Details
Published in:Catalysis communications 2005-08, Vol.6 (8), p.520-524
Main Authors: Zsigmond, Ágnes, Kecskeméti, Anita, Bogár, Krisztián, Notheisz, Ferenc, Mernyák, Erzsébet
Format: Article
Language:English
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Summary:Racemization of optically active secondary alcohols was performed on a heterogeneous Ru/Al 2O 3 catalyst under mild reaction conditions. The supported ruthenium catalyst is readily available, inexpensive, and capable of being recycled. It successfully racemizes secondary alcohols without any additive or cocatalyst. A convenient synthesis of an expensive steroid alcohol was developed applying the same reaction conditions.
ISSN:1566-7367
1873-3905
DOI:10.1016/j.catcom.2005.04.020