Xanthan sulfuric acid: A new and efficient bio-supported solid acid catalyst for the synthesis of α-amino nitriles by condensation of carbonyl compounds, amines, and trimethylsilylcyanide

In this work, α-amino nitriles are synthesized by a three-component one-pot condensation reaction of aldehydes or ketones, amines and trimethylsilylcyanide in the presence of a catalytic amount of xanthan sulfuric acid as a new bio-supported catalyst, in excellent yields with short reaction times at...

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Bibliographic Details
Published in:Catalysis communications 2009-02, Vol.10 (6), p.945-949
Main Authors: Shaabani, Ahmad, Maleki, Ali, Soudi, Mohammad Reza, Mofakham, Hamid
Format: Article
Language:English
Subjects:
Bio-supported catalyst
Three-component reaction
Trimethylsilylcyanide
Xanthan sulfuric acid
α-Amino nitriles
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Summary:In this work, α-amino nitriles are synthesized by a three-component one-pot condensation reaction of aldehydes or ketones, amines and trimethylsilylcyanide in the presence of a catalytic amount of xanthan sulfuric acid as a new bio-supported catalyst, in excellent yields with short reaction times at ambient temperature. The xanthan as the base of the catalyst was produced biologically from a native strain, i.e. xanthomonas campestris strain b82. The reaction procedure is simple and the catalyst can be easily separated from the reaction mixture and reused in subsequent reactions.
ISSN:1566-7367
1873-3905
DOI:10.1016/j.catcom.2008.12.035