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Environmentally friendly [Pd/Cu]-catalysed C3-alkenylation of free NH-indoles
A new eco-efficient and environmentally friendly palladium/copper catalytic procedure for the C3-alkenylation of free NH-indoles is reported. Using homogeneous or heterogeneous heterobimetallic [Pd/Cu]-catalysts under mild reaction conditions (10 mol% Pd-catalyst and 10 mol% Cu-catalyst, 70 °C, air)...
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Published in: | Catalysis today 2009-02, Vol.140 (1), p.90-99 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A new eco-efficient and environmentally friendly palladium/copper catalytic procedure for the C3-alkenylation of free NH-indoles is reported. Using homogeneous or heterogeneous heterobimetallic [Pd/Cu]-catalysts under mild reaction conditions (10
mol% Pd-catalyst and 10
mol% Cu-catalyst, 70
°C, air), substituted indoles are fully (58–82% isolated yields) and selectively (75–100% selectivity) converted to the expected 2-substituted-3-vinylindoles. |
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ISSN: | 0920-5861 1873-4308 |
DOI: | 10.1016/j.cattod.2008.07.013 |