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Environmentally friendly [Pd/Cu]-catalysed C3-alkenylation of free NH-indoles

A new eco-efficient and environmentally friendly palladium/copper catalytic procedure for the C3-alkenylation of free NH-indoles is reported. Using homogeneous or heterogeneous heterobimetallic [Pd/Cu]-catalysts under mild reaction conditions (10 mol% Pd-catalyst and 10 mol% Cu-catalyst, 70 °C, air)...

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Bibliographic Details
Published in:Catalysis today 2009-02, Vol.140 (1), p.90-99
Main Authors: Djakovitch, Laurent, Rouge, Pascal
Format: Article
Language:English
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Summary:A new eco-efficient and environmentally friendly palladium/copper catalytic procedure for the C3-alkenylation of free NH-indoles is reported. Using homogeneous or heterogeneous heterobimetallic [Pd/Cu]-catalysts under mild reaction conditions (10 mol% Pd-catalyst and 10 mol% Cu-catalyst, 70 °C, air), substituted indoles are fully (58–82% isolated yields) and selectively (75–100% selectivity) converted to the expected 2-substituted-3-vinylindoles.
ISSN:0920-5861
1873-4308
DOI:10.1016/j.cattod.2008.07.013