Biocatalysis in drug discovery and development

Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is beginning to transform chemical synthesis in the pharmaceutical industry. This review presents recent examples of the creative use of biocatalysis to enable drug discovery and development. We illustrate how incre...

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Bibliographic Details
Published in:Current opinion in chemical biology 2020-04, Vol.55, p.151-160
Main Authors: Fryszkowska, Anna, Devine, Paul N.
Format: Article
Language:English
Subjects:
Alkylation
Biocatalysis
Biotransformation
Chemistry, Pharmaceutical - methods
Drug Discovery
Drug Industry
Enzymes - metabolism
Indoles - chemical synthesis
Metals - chemistry
Oxidation-Reduction
Peptides - chemical synthesis
Photochemical Processes
Protein Engineering
Pyrimidines - chemical synthesis
Pyrroles - chemical synthesis
Stereoisomerism
Transition Elements - chemistry
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Summary:Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is beginning to transform chemical synthesis in the pharmaceutical industry. This review presents recent examples of the creative use of biocatalysis to enable drug discovery and development. We illustrate how increased access to novel biotransformations and the rise of cascade biocatalysis allowed fundamentally new syntheses of novel medicines, representing progress toward more sustainable pharmaceutical manufacturing. Finally, we describe the opportunities and challenges the industry must address to ensure the reduction to practice of biotechnological innovations to develop new therapies in a faster, more economical, and environmentally benign way.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2020.01.012