Responses of growth inhibition and antioxidant gene expression in earthworms (Eisenia fetida) exposed to tetrabromobisphenol A, hexabromocyclododecane and decabromodiphenyl ether

Tetrabromobisphenol A (TBBPA), hexabromocyclododecane (HBCD) and decabromodiphenyl ether (BDE 209), suspected ubiquitous contaminants, account for the largest volume of brominated flame retardants (BFRs) since penta-BDE and octa-BDE have been phased out globally. In this paper, the growth inhibition...

Full description

Saved in:
Bibliographic Details
Published in:Comparative biochemistry and physiology. Toxicology & pharmacology 2015-08, Vol.174-175, p.32-38
Main Authors: Shi, Ya-juan, Xu, Xiang-bo, Zheng, Xiao-qi, Lu, Yong-long
Format: Article
Language:English
Subjects:
Animals
Antioxidant enzymes
Antioxidants - metabolism
BDE 209
Brominated flame retardants
Catalase - genetics
Catalase - metabolism
Environmental Exposure - adverse effects
Flame Retardants - adverse effects
Gene expression
Gene Expression - drug effects
Gene Expression - genetics
Growth inhibition
Halogenated Diphenyl Ethers - adverse effects
HBCD
Heat shock proteins
HSP70 Heat-Shock Proteins - genetics
HSP70 Heat-Shock Proteins - metabolism
Hydrocarbons, Brominated - adverse effects
Oligochaeta - drug effects
Oligochaeta - genetics
Oligochaeta - metabolism
Oxidative Stress - drug effects
Oxidative Stress - genetics
Polybrominated Biphenyls - adverse effects
RNA, Messenger - genetics
Superoxide Dismutase - genetics
Superoxide Dismutase - metabolism
TBBPA
Up-Regulation - drug effects
Up-Regulation - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tetrabromobisphenol A (TBBPA), hexabromocyclododecane (HBCD) and decabromodiphenyl ether (BDE 209), suspected ubiquitous contaminants, account for the largest volume of brominated flame retardants (BFRs) since penta-BDE and octa-BDE have been phased out globally. In this paper, the growth inhibition and gene transcript levels of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT)) and the stress-response gene involved in the prevention of oxidative stress (Hsp70) of earthworms (Eisenia fetida) exposed to TBBPA, HBCD and BDE 209 were measured to identify the toxicity effects of selected BFRs on earthworms. The growth of earthworms treated by TBBPA at 200 and 400mg/kg dw were inhibited at rate of 13.7% and 22.0% respectively, while there was no significant growth inhibition by HBCD and BDE 209. A significant (P
ISSN:1532-0456
1878-1659
DOI:10.1016/j.cbpc.2015.06.005