Ameliorative effect of vitamins (E and C) on biochemical alterations induced by sublethal concentrations of zinc oxide bulk and nanoparticles in Oreochromis niloticus

The comparison between bulk and nano ZnO particles were antecedently studied but describing the dose-dependent toxicity and the ameliorative effect of vitamins (E and C) in Oreochromis niloticus, have not been previously documented. Therefore, the present study was designed to investigate the amelio...

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Published in:Comparative biochemistry and physiology. Toxicology & pharmacology 2021-04, Vol.242, p.108952, Article 108952
Main Authors: Mohamed, Amal Said, Soliman, Hanan Abdelhameid, Ghannam, Hala Elshahat
Format: Article
Language:English
Subjects:
Antioxidant enzymes
O. niloticus
Vitamins (E and C)
ZnOBPs
ZnONPs
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Summary:The comparison between bulk and nano ZnO particles were antecedently studied but describing the dose-dependent toxicity and the ameliorative effect of vitamins (E and C) in Oreochromis niloticus, have not been previously documented. Therefore, the present study was designed to investigate the ameliorative effect of vitamins (E and C) against oxidative stress and biochemical alterations induced by sublethal concentrations of zinc oxide bulk particles (ZnOBPs) and zinc oxide nanoparticles (ZnONPs). Toxicity tests were carried out on O. niloticus and showed that 96 h LC50 values of ZnOBPs and ZnONPs were 84 mg/l and 5.6 mg/l respectively. Exposure of the studied fish to these sublethel concentrations for 7, 14, 21 & 28 days showed a significant increase (p 
ISSN:1532-0456
1878-1659
DOI:10.1016/j.cbpc.2020.108952