Short- and long-term exposures of the synthetic cannabinoid 5F-APINAC induce metabolomic alterations associated with neurotransmitter systems and embryotoxicity confirmed by teratogenicity in zebrafish

Synthetic cannabinoids are abused substances with strong psychoactive effects. Little is known about the effects on neurotransmission and the toxicity of the second-generation cannabinoid 5F-APINAC. The objective was to assess the influence of short- and long-term exposures of 5F-APINAC on metabolit...

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Bibliographic Details
Published in:Comparative biochemistry and physiology. Toxicology & pharmacology 2021-05, Vol.243, p.109000, Article 109000
Main Authors: Markin, Pavel A., Brito, Alex, Moskaleva, Natalia E., Tagliaro, Franco, La Frano, Michael R., Savitskii, Mark V., Appolonova, Svetlana A.
Format: Article
Language:English
Subjects:
5F-APINAC
Metabolites
Metabolomics
Neurotransmission
Novel psychoactive substances
Synthetic cannabinoids
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Summary:Synthetic cannabinoids are abused substances with strong psychoactive effects. Little is known about the effects on neurotransmission and the toxicity of the second-generation cannabinoid 5F-APINAC. The objective was to assess the influence of short- and long-term exposures of 5F-APINAC on metabolites associated with neurotransmission on zebrafish. Short-term (“acute”, 4 h) and long-term (“chronic”, 96 h) exposures to 5F-APINAC were performed at 0.001, 0.01, 0.1, 1.0 and 10 μM. Intervention groups were compared with a vehicle control. Each group n = 20 zebrafish eggs/larvae. Metabolites related to neurotransmission were determined. In chronic exposure, larvae exposed to 10 μM 5F-APINAC presented morphological and developmental alterations. GABA had the lowest concentrations at higher exposure in acute (p 
ISSN:1532-0456
1878-1659
DOI:10.1016/j.cbpc.2021.109000