Toxic effects of ZnSe/ZnS quantum dots on the reproduction and genotoxiticy of rare minnow (Gobiocypris rarus)

ZnSe/ZnS quantum dots (QDs) have excellent optical properties, but researchers have not clearly determined whether they cause harm to organisms. In the present study, the effect of ZnSe/ZnS QDs on the parents and offspring of rare minnow were evaluated for the first time. Exposure to ZnSe/ZnS QDs al...

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Published in:Comparative biochemistry and physiology. Toxicology & pharmacology 2021-09, Vol.247, p.109065, Article 109065
Main Authors: Ding, Yanhong, Yang, Yang, Chen, Juan, Chen, Hang, Wu, Yingyi, Jin, Li
Format: Article
Language:English
Subjects:
Genetic toxicity
Gobiocypris rarus
Growth and developmental toxicity
Reproductive toxicity
ZnSe/ZnS QDs
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Summary:ZnSe/ZnS quantum dots (QDs) have excellent optical properties, but researchers have not clearly determined whether they cause harm to organisms. In the present study, the effect of ZnSe/ZnS QDs on the parents and offspring of rare minnow were evaluated for the first time. Exposure to ZnSe/ZnS QDs altered the testicular structure, caused sperm DNA damage and decreased sperm motility in males. They also suppressed the expression of reproduction-related genes, such as androgen receptor (Ar), DM-related transcription factor 1 (Dmrt1), estrogen receptor (Er), and X-ray repair cross complementing gene 1 (Xrcc1). Continued monitoring of the F1 generation revealed that the embryonic development of the F1 generation was abnormal and the growth index of the F1 generation of adult fish showed hormesis. A comet assay showed that the F1 generation still had DNA damage in the 400 and 800 nmol/L groups at 96 h post-fertilization (hpf). Thus, ZnSe/ZnS QDs damaged the reproductive system of the rare minnow, and this effect continued to the F1 generation. •Test the growth and development of the F1 generation after the parents are exposed to quantum dots.•After the parents were treated with quantum dots, Hormesis appears in F1 generation.•In the high concentration group, DNA damage was observed in F1 embryos.•inhibit the expression of the parental testis Ar and Dmrt1 and other reproduction-related genes.•the structure of the male testis is changed, and parental sperm DNA damage occurs while sperm motility decreases.
ISSN:1532-0456
1878-1659
DOI:10.1016/j.cbpc.2021.109065