Paraoxonase: A multifaceted biomolecule

Paraoxonase enzyme was first identified as a protective barrier against organophosphorus poisoning. After painstaking research spanning the last three decades, the knowledge about this enzyme has increased immensely. The present review attempts to elaborate the role of paraoxonase enzyme in normal p...

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Bibliographic Details
Published in:Clinica chimica acta 2009-12, Vol.410 (1), p.1-12
Main Authors: Goswami, Binita, Tayal, Devika, Gupta, Nikhil, Mallika, V.
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Aryldialkylphosphatase - physiology
Cancer
Cirrhosis
Coronary artery disease
Disease Susceptibility - enzymology
Endometriosis
Hepatitis
Humans
Lead poisoning
Mixed connective tissue disorders
Organophosphorus poisoning
Paraoxonase
Polycystic ovarian syndrome
Polymorphisms
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Summary:Paraoxonase enzyme was first identified as a protective barrier against organophosphorus poisoning. After painstaking research spanning the last three decades, the knowledge about this enzyme has increased immensely. The present review attempts to elaborate the role of paraoxonase enzyme in normal physiology as well as provide an overview of the various disorders in which the enzyme may have a role in etiopathogenesis. The literature was searched from the websites of the National Library of Medicine ( http://www.ncbi.nlm.nih.gov/) and Pub Med Central, the U.S. National Library of Medicine's digital archive of life sciences journal literature. Paraoxonase acts as an important antioxidant enzyme against oxidative stress. The enzyme has been implicated in the pathogenesis of a number of disorders including cardiovascular disorders, cancers etc. A better understanding of the molecular mechanism of the enzyme along with the regulatory circuits will help us to utilize agonists to potentiate the anti oxidant actions of the enzyme.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2009.09.025