Low serum sex hormone-binding globulin: Marker of inflammation?

Low sex hormone-binding globulin (SHBG) is associated with metabolic syndrome (MetS), but its relationship with inflammation is unclear. This cross-sectional study included 696 subjects (255 men, 235 pre-menopausal women, and 206 postmenopausal women). Body mass index, waist circumference, blood pre...

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Bibliographic Details
Published in:Clinica chimica acta 2012-04, Vol.413 (7-8), p.803-807
Main Authors: Liao, Chun-Hou, Li, Hung-Yuan, Yu, Hong-Jeng, Chiang, Han-Sun, Lin, Mao-Shin, Hua, Cyue-Huei, Ma, Wen-Ya
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
C-reactive protein
Female
Humans
Inflammation
Inflammation - blood
Metabolic syndrome
Middle Aged
Multivariate Analysis
Sex hormone
Sex Hormone-Binding Globulin - metabolism
Sex-hormone binding globulin
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Summary:Low sex hormone-binding globulin (SHBG) is associated with metabolic syndrome (MetS), but its relationship with inflammation is unclear. This cross-sectional study included 696 subjects (255 men, 235 pre-menopausal women, and 206 postmenopausal women). Body mass index, waist circumference, blood pressure, lipid profiles, plasma glucose, insulin, FSH, LH, total testosterone (TT), estradiol, SHBG, dehydroepiandrosterone sulfate (DHEA-S), and hs-CRP concentrations were measured. MetS was defined according to the updated National Cholesterol Education Program criteria with modification of waist circumference for Asians. Serum hs-CRP and SHBG were negatively correlated in men (r=−0.29, p
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2012.01.021