Study on disulfur-backboned nucleic acids: Part IV. Efficient synthesis of 3′,5′-dithio-2′-deoxyguanosine

An efficient and novel method for synthesizing 3′,5′-dithio-2′-deoxyguanosine was described. In this method normal guanosine was used as the starting material. A very efficient procedure was used to synthesize 2́- O-tosylguanosine 1, which used 0.1 eq. DBTO instead of 2 eq. 1 was treated with LTBH t...

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Bibliographic Details
Published in:Chinese chemical letters 2010-02, Vol.21 (2), p.131-134
Main Authors: Shang, Pei Hua, Cheng, Chang Mei, Wang, Hua, Zheng, Hong Chao, Zhao, Yu Fen
Format: Article
Language:English
Subjects:
3́,5́-Dithio-2́-deoxyguanosine
Guanosine
Synthesis
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Summary:An efficient and novel method for synthesizing 3′,5′-dithio-2′-deoxyguanosine was described. In this method normal guanosine was used as the starting material. A very efficient procedure was used to synthesize 2́- O-tosylguanosine 1, which used 0.1 eq. DBTO instead of 2 eq. 1 was treated with LTBH to give 9-(2-deoxy- β- d-threo-pentofuranosyl)guanine 2. 2 could be easily turned to the target compound.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2009.10.017