First synthesis and characterization of key stereoisomers related to Ezetimibe

uring the laboratory optimization and the late phase manufacturing studies of the cholesterol absorption inhibitor Ezetimibe 1, the formation of several stereoisomers was observed. To study the complete stereoisomer profile of Ezetimibe 1, we have synthesized and completely characterized several key...

Full description

Saved in:
Bibliographic Details
Published in:Chinese chemical letters 2014-08, Vol.25 (8), p.1157-1160
Main Authors: Ren, Yun, Duan, Yan-Jun, Li, Ren-Jun, Deng, Yong, Hai, Li, Wu, Yong
Format: Article
Language:English
Subjects:
Characterization
Ezetimibe
Related substances
Stereoisomers profile
Synthesis
参考标准
合成
实验室
抑制剂
立体异构体
胆固醇
表征
麦
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:uring the laboratory optimization and the late phase manufacturing studies of the cholesterol absorption inhibitor Ezetimibe 1, the formation of several stereoisomers was observed. To study the complete stereoisomer profile of Ezetimibe 1, we have synthesized and completely characterized several key stereoisomers of Ezetimibe 1 for the first time. This study will provide an access to the reference standard of these stereoisomers and may have some implications in the development of new medicines.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2014.03.035