Nickel-catalyzed cross-coupling reaction of alkynyl bromides with Grignard reagents

We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of （bromoethynyl）benzene with Grignard reagents. The reaction of （bromoethynyl）benzene （1 mmol） with Grignard reagent （1.3 mmol） mediated by NiCl2 （4 mol%） and （p-CH3Ph）3P （8 mol%） in THF...

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Bibliographic Details
Published in:Chinese chemical letters 2014-09, Vol.25 (9), p.1296-1300
Main Authors: Li, Qing-Han, Ding, Yong, Yang, Xue-Jun
Format: Article
Language:English
Subjects:
(Bromoethynyl)benzene
1,2-Disubstituted acetylene
Cross-coupling
Grignard reagent
Nickel
THF
乙炔基
二取代
交叉偶联反应
摩尔
格氏试剂
溴化物
镍催化
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Summary:We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of （bromoethynyl）benzene with Grignard reagents. The reaction of （bromoethynyl）benzene （1 mmol） with Grignard reagent （1.3 mmol） mediated by NiCl2 （4 mol%） and （p-CH3Ph）3P （8 mol%） in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2014.04.019