Green synthesis of 1,2,4-thiadizoles from thioamides in water using molecular oxygen as an oxidant

We present here an efficient green process for the synthesis of 1,2,4-thiadiazoles via iodine-catalyzed,oxidative dimerization of thioamides in water using molecular oxygen as a terminal oxidant. Under the optimized reaction conditions, aryl thioamides produced 3,5-diaryl-1,2,4-thiadiazoles in good...

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Bibliographic Details
Published in:Chinese chemical letters 2014-11, Vol.25 (11), p.1499-1502
Main Authors: Zhao, Jin-Wu, Xu, Jing-Xiu, Guo, Xiu-Zhen
Format: Article
Language:English
Subjects:
1,2,4-Thiadizole
4-噻二唑
Oxygen
Thioamide
Water
分子氧
反应条件
氧化剂
水
硫代酰胺
绿色合成
绿色工艺
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Summary:We present here an efficient green process for the synthesis of 1,2,4-thiadiazoles via iodine-catalyzed,oxidative dimerization of thioamides in water using molecular oxygen as a terminal oxidant. Under the optimized reaction conditions, aryl thioamides produced 3,5-diaryl-1,2,4-thiadiazoles in good to excellent yields. Alkyl thioamides and substituted thioureas could also provide corresponding 1,2,4-thiadiazole products.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2014.05.019