A novel method for the synthesis of sulfur substituted-cyclopyrophosphate of cADPR analogs

A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE（P_S~1-cIDPRE） was developed.The key step was the cyclization process which was completed by the sulfur substituted cyclization precursor 1b via the one-pot phosphoramidite strategy.

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Bibliographic Details
Published in:Chinese chemical letters 2014-12, Vol.25 (12), p.1583-1585
Main Authors: Wu, Ren-Min, Qi, Na, Jia, Yu-Wen, Guan, Zhu, Zhang, Liang-Ren, Zhang, Li-He, Yang, Zhen-Jun
Format: Article
Language:English
Subjects:
cADPR
cIDPRE
Cyclopyrophosphate
Phosphoramidite strategy
前体
合成
核糖
环化
硫
类似物
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Description
Summary:A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE（P_S~1-cIDPRE） was developed.The key step was the cyclization process which was completed by the sulfur substituted cyclization precursor 1b via the one-pot phosphoramidite strategy.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2014.07.010