Prenylated indole alkaloids from the marine-derived fungus Paecilomyces variotii

Two new prenylated indole alkaloids,namely,dihydrocarneamide A（1） and iso-notoamide B（2）,were isolated from the marine-derived endophytic fungus Paecilomyces variotii EN-291.The structures of these metabolites were determined based on comprehensive spectral analysis,together with chiral HPLC analysi...

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Bibliographic Details
Published in:Chinese chemical letters 2015-03, Vol.26 (3), p.313-316
Main Authors: Zhang, Peng, Li, Xiao-Ming, Wang, Jia-Ning, Li, Xin, Wang, Bin-Gui
Format: Article
Language:English
Subjects:
Cytotoxicity
HPLC
Indolediketopiperazine
Marine algal-derived fungus
Natural products
Paecilomyces variotii
内生真菌
吲哚生物碱
异戊烯基
拟青霉
海洋真菌
细胞毒活性
衍生
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Summary:Two new prenylated indole alkaloids,namely,dihydrocarneamide A（1） and iso-notoamide B（2）,were isolated from the marine-derived endophytic fungus Paecilomyces variotii EN-291.The structures of these metabolites were determined based on comprehensive spectral analysis,together with chiral HPLC analysis of the acidic hydrolysates.Unlike other prenylated indole alkaloids such as asperparalines,notoamides,and versicolamides,compounds 1 and 2 are the rare examples of C-5 prenylation,forming the fused dimethyldihydropyran ring at C-5 and C-6 of the indole ring.The cytotoxic activity of the isolated compounds was evaluated.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2014.11.020