Direct amination of pyrimidin-2-yl tosylates with aqueous ammonia under metal-free and mild conditions

A metal-flee synthesis of pyrimidine functionalized primary amines via direct amination of pyrimidin-2- yl tosylate with aqueous ammonia has been developed under mild conditions. The desired products pyrimidin-2-amines can be generated in excellent yields in PEG-400, without any catalysts or other a...

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Bibliographic Details
Published in:Chinese chemical letters 2015-06, Vol.26 (6), p.667-671
Main Authors: Gong, Hai-Peng, Zhang, Yue, Da, Yu-Xia, Zhang, Zhang, Quan, Zheng-Jun, Wang, Xi-Cun
Format: Article
Language:English
Subjects:
2-Aminopyrimidines
Ammonia
PEG-400
Pyrimidin-2-yl tosylate
嘧啶
氨水
水下
添加剂
甲苯磺酸酯
直接胺化
金属
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Summary:A metal-flee synthesis of pyrimidine functionalized primary amines via direct amination of pyrimidin-2- yl tosylate with aqueous ammonia has been developed under mild conditions. The desired products pyrimidin-2-amines can be generated in excellent yields in PEG-400, without any catalysts or other additives.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2015.01.034