Water dispersible hydroxyapatite nanoparticles functionalized by a family of aminoalkyl phosphates

A series of aminoalkyi phosphates（AAP-n,with carbon number n ranging from 2 to 6） are used as surface modifiers to prepare hydroxyapatite hydrocolloids.The resulting nanoparticles（Cn-HA） possess a coreshell structure where an ionized layer of calcium-（AAP-n） complex[^＋H3N-（CH2）n-OPO3Ca]encapsulates...

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Bibliographic Details
Published in:Chinese chemical letters 2015-09, Vol.26 (9), p.1121-1128
Main Authors: Jiang, Yi-Rou, Sun, Fu-Hua, Zhou, Xiao-Yong, Kong, Wei-Bo, Xie, Xing-Yi
Format: Article
Language:English
Subjects:
Aminoalkyl phosphate
Cytotoxicity
Hydrocolloid
Hydroxyapatite
官能化
家庭
材料制备
水分散性
烷基
磷酸盐
纳米羟基磷灰石
聚合物复合材料
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Summary:A series of aminoalkyi phosphates（AAP-n,with carbon number n ranging from 2 to 6） are used as surface modifiers to prepare hydroxyapatite hydrocolloids.The resulting nanoparticles（Cn-HA） possess a coreshell structure where an ionized layer of calcium-（AAP-n） complex[^＋H3N-（CH2）n-OPO3Ca]encapsulates each hydroxyapatite core.Long-term colloidal stability is achieved due to the electrostatic repulsion among the suspending particles.The incorporation of AAP-n results in a preferential crystal growth along c-axis,showing an increasing aspect ratio of particles from C2-HA to C6-HA.Preliminary cell culture using osteoblast-like MG63 cells shows no cytotoxicity associated with the as-prepared Cn-HA particles.The functional amino groups around the nanoparticles could be used to graft various organic chains to prepare homogeneous HA/polymer composites as bone grafting materials.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2015.04.035