Design, synthesis and insecticidal activity of biphenyl-diamide derivatives

Diamides acting on insect ryanodine receptors are an intensive research area now. In order to search for novel candidates, a series of diamides containing biphenyl substructure were designed and synthesized.Their insecticidal activities against armyworms（Mythimna sepatara） and aphis（Aphis craccivora...

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Bibliographic Details
Published in:Chinese chemical letters 2016-03, Vol.27 (3), p.321-324
Main Authors: Liu, Ye, Lei, Chao, Xu, Xiao-Yong, Shao, Xu-Sheng, Li, Zhong
Format: Article
Language:English
Subjects:
Biphenyl
Diamide
Insecticide
Ryanodine insecticide
二酰胺
候选人
先导化合物
杀虫活性成分
相似症状
联苯结构
设计合成
酰胺衍生物
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Summary:Diamides acting on insect ryanodine receptors are an intensive research area now. In order to search for novel candidates, a series of diamides containing biphenyl substructure were designed and synthesized.Their insecticidal activities against armyworms（Mythimna sepatara） and aphis（Aphis craccivora） were screened. The compounds with 3,5-dichloro-4-（1,1,2,2-tetrafluoroethoxy）phenyl substituent were found to be insecticidal to armyworms with the similar symptoms to poisoning by flubendiamide. In this research, we presented a novel type of diamide insecticide as a lead compound for further optimization.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2015.12.011