Synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by α-chymotrypsin

α-Chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aldehydes with 2-aminobenzamides to afford the corresponding 2,3-dihydroquinazolin-4(1H)-ones. [Display omitted] We discovered that α-chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aromatic and...

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Bibliographic Details
Published in:Chinese chemical letters 2017-01, Vol.28 (1), p.101-104
Main Authors: Zhang, Shi-Guo, Xie, Zong-Bo, Liu, Lian-Sheng, Liang, Meng, Le, Zhang-Gao
Format: Article
Language:English
Subjects:
2,3-Dihydroquinazolin-4(1H)-ones
2-Aminobenzamides
Biocatalysis
Cyclocondensation
α-Chymotrypsin
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Summary:α-Chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aldehydes with 2-aminobenzamides to afford the corresponding 2,3-dihydroquinazolin-4(1H)-ones. [Display omitted] We discovered that α-chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aromatic and aliphatic aldehydes with 2-aminobenzamides to afford the corresponding 2,3-dihydroquinazolin-4(1H)-ones successfully in high yields (90%–98%) under alcohol solvent. The catalytic activity of α-chymotrypsin was evaluated through investigating the temperature, the enzyme loading and the ratio of substrates in the enzyme-catalyzed reactions. The present method proves to be efficient and environmentally friendly in terms of short reaction time, high yield, green catalyst and the clean products obtained without further purification processes.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2016.06.001