Sulfamic acid as a green, reusable catalyst for stepwise, tandem ＆ one-pot solvent-free synthesis of pyrazole derivatives

Sulfamic acid（SA） is a bi-functional, cost-effective and reusable green catalyst for the synthesis of 4-（pyrazol-4-yl）methylenepyrazol-5（4H）-one derivatives by one-pot, three-component condensation of pyrazol-4-carbaxaldehydes, b-ketoesters and phenyl hydrazine（Route-I）. In addition to this method,a...

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Bibliographic Details
Published in:Chinese chemical letters 2017-07, Vol.28 (7), p.1571-1576
Main Authors: Konkala, Veera Swamy, Dubey, Pramod Kumar
Format: Article
Language:English
Subjects:
Knoevenagel condensation
Multicomponent reaction
Physical grinding
Pyrazol-4-carbaxaldehydes
Sulfamic acid
串联
可重复使用
吡唑衍生物
固体酸催化剂
无溶剂合成
无溶剂条件
氨基磺酸
绿色催化剂
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Summary:Sulfamic acid（SA） is a bi-functional, cost-effective and reusable green catalyst for the synthesis of 4-（pyrazol-4-yl）methylenepyrazol-5（4H）-one derivatives by one-pot, three-component condensation of pyrazol-4-carbaxaldehydes, b-ketoesters and phenyl hydrazine（Route-I）. In addition to this method,another simple condensation of pyrazol-4-carbaxaldehydes with pyrazolone in the presence of SA under the solvent-free condition in good yield is reported. The merits of these protocols are mild conditions,non-aqueous workup, high yields, easy availability of the catalyst, no chromatographic separation and inexpensive solid acid catalyst. Furthermore, SA could be recycled and reused for five times without losing its catalytic activity.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2017.02.005