Two pairs of chlorine-containing phenylpropanoid enantiomers from Acorus tatarinowii

Two pairs of chlorine-containing phenylpropanoid enantiomers（1a/1b and 2a/2b） were isolated from the rhizomes of Acorus tatarinowii. Interestingly, these optical isomers（1a/1b and 2a/2b） were co-existed in the same plant, which were characterized as the first halogen-containing natural products from...

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Bibliographic Details
Published in:Chinese chemical letters 2017-07, Vol.28 (7), p.1460-1464
Main Authors: Lu, Yuan-Yuan, Gong, Xue-Peng, Xue, Yong-Bo, Zhu, Hu-Cheng, Li, Xiao-Nian, Hu, Lin-Zhen, Guan, Jian-Kun, Zhang, Jin-Wen, Du, Guang, Zhang, Yong-Hui
Format: Article
Language:English
Subjects:
Acorus tatarinowii
Antioxidant activity
Chlorine-containing phenylpropanoid
Cytotoxicity
DPPH法
Enantiomers
X射线单晶衍射法
光学异构体
对映体
氯
石菖蒲
细胞毒活性
苯丙氨酸
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Summary:Two pairs of chlorine-containing phenylpropanoid enantiomers（1a/1b and 2a/2b） were isolated from the rhizomes of Acorus tatarinowii. Interestingly, these optical isomers（1a/1b and 2a/2b） were co-existed in the same plant, which were characterized as the first halogen-containing natural products from the genus Acorus. Their structures and absolute configurations were elucidated by a combination of spectroscopic analysis and a single-crystal X-ray diffraction, assisted by a modified Mosher＇s method. The phenylpropanoid isomers（1a/1b and 2a/2b） were evaluated for their antioxidant activities using DPPH assay and cytotoxic activities against five human cancer cell lines.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2017.03.024