Synthesis and insecticidal activities of 1,8-naphthyridine derivatives

1,8-Naphthyridines（NAP） are biological important scaffolds in bioactive molecules design. By hybrid of NAP with neonicotinoid core structure, nine novel NAP derivatives were synthesized and subjected to insecticidal activities evaluation. Some of the compounds showed excellent insecticidal activity...

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Bibliographic Details
Published in:Chinese chemical letters 2017-08, Vol.28 (8), p.1723-1726
Main Authors: Hou, Qing-Qing, Jing, Yi-Fei, Shao, Xu-Sheng
Format: Article
Language:English
Subjects:
1,8-Naphthyridine
Aphid
Insecticide ativity
NAP
Neonicotinoid
合成
支架材料
杀虫活性
活性评价
烟碱类
生物活性分子
衍生物
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Summary:1,8-Naphthyridines（NAP） are biological important scaffolds in bioactive molecules design. By hybrid of NAP with neonicotinoid core structure, nine novel NAP derivatives were synthesized and subjected to insecticidal activities evaluation. Some of the compounds showed excellent insecticidal activity against cowpea aphids（Aphis craccivora） with LC_（50） values ranging from 0.011 mmol/L to 0.067 mmol/L. The results indicated that 1,8-naphthyridine can be used as insecticidal structure for further modification.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2017.05.016