Biocompatible microcapsules with a water core templated from single emulsions

• Published in: Chinese chemical letters 2017-09, Vol.28 (9), p.1897-1900
• Main Authors: Kong, Linlin, Amstad, Esther, Hai, Mingtan, Ke, Xinyou, Chen, Dong, Zhao, Chun-Xia, Weitz, David A.
• Format: Article
• Language: English
• Subjects: Biocompatible; Hydrophilic actives; Microcapsule; Microfluidic; Single emulsion; 乳液; 亲水; 模板; 流控技术; 涂层改性; 生物微胶囊; 聚合物分散液; 聚电解质
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2017.07.017

Biocompatible microcapsules with a water core are widely used to encapsulate hydrophilic actives.Here,a facile method to fabricate monodisperse biocompatible microcapsules with a water core in large quantity is reported.Microfluidic technology is utilized to emulsify the inner aqueous phase containing the shell polymer into monodisperse drops in the outer oil phase.As the cosolvent in the inner aqueous phase diffuses into the outer oil phase,the solubility of the shell polymer decreases,which eventually precipitates.Since the shell polymer,shellac,contains both hydrophilic and hydrophobic groups,it tends to wet both the inner aqueous phase and the outer oil phase,thus forming a solid shell at the periphery of the drop.We show that the diffusion rate of hydrophilic molecules encapsulated in the water core decreases as their molecular weight increases and the property of the microcapsules could further be modified by polyelectrolyte multilayer coating.These microcapsules are fabricated using FDA-approved polymer and non-toxic solvents and are of great use in drugs,cosmetics and foods.