A new cytotoxic salannin-class limonoid alkaloid from seeds of Azadirachta indica A. Juss

[Display omitted] Azadiramide A (1), a new salannin-class limonoid alkaloid, inhibits growth of human breast cancer MDA-MB-231 cell line with IC50 value of 2.70±0.63μmol/L. A new cytotoxic salannin-class limonoid alkaloid, azadiramide A (1), was isolated from seeds of Azadirachta indica A. Juss. Its...

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Bibliographic Details
Published in:Chinese chemical letters 2018-08, Vol.29 (8), p.1261-1263
Main Authors: Zhu, Jianxun, Lu, Xiaofeng, Fan, Xiaona, Wu, Ruibo, Diao, Hongjuan, Yu, Rongmin, Xu, Hanhong, Zi, Jiachen
Format: Article
Language:English
Subjects:
Alkaloid
Azadirachta indica
Cytotoxic activity
Limonoid
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Summary:[Display omitted] Azadiramide A (1), a new salannin-class limonoid alkaloid, inhibits growth of human breast cancer MDA-MB-231 cell line with IC50 value of 2.70±0.63μmol/L. A new cytotoxic salannin-class limonoid alkaloid, azadiramide A (1), was isolated from seeds of Azadirachta indica A. Juss. Its structure was elucidated by extensive analysis of spectroscopic data and quantum chemical calculation. Compound 1 is a rare salannin-class limonoid alkaloid. To our best knowledge, only two compounds belonging to this type were so far found. It showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC50 value of 2.70±0.63μmol/L.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2017.11.042